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When combining these agents, patients may experience additive gastrointestinal effects, though clinical trial data suggest the combination is generally well-tolerated when appropriate dose titration strategies are employed

Kaur G., Singh A., Arora G., et al., Synthetic Heterocyclic Derivatives as Promising Xanthine Oxidase Inhibitors: An Overview, Chemical Biology & Drug Design 100 (2022): 443468, 10.1111/cbdd.14109